Cro Molecules

Physical Properties :

Chemical Name: (2R)-2-Deoxy-2-fluoro-2-methyl-D-erythropentonic acid gamma-lactone 3,5-dibenzoate
CAS.NO:  874638-80-9
Synonyms:
[(2R,3R,4R)-3-benzoyloxy-4-fluoro-4-methyl-5-oxooxolan-2-yl]methyl benzoate
[(2R,3R,4R)-3-(Benzoyloxy)-4-fluoro-4-methyl-5-oxotetrahydro-2-furanyl]methyl benzoate
((2R,3R,4R)-3-(benzoyloxy)-4-fluoro-4-methyl-5-oxotetrahydrofuran-2-yl)methyl benzoate

Molecular Formula: C20H17FO6
Molecular Weight:   372.34400

Physical and Chemical Properties:
Density: 1.3±0.1 g/cm3
Boiling point: 458.6±34.0 °C at 760 mmHg
Melting point: 133℃
Flash point: 222.9±20.6 °C
Refractive index: 1.577

Specification:
Appearance:   White powder
Purity:≥98.0%
Loss on Drying:No more than 0.5%

Packing:
 25kg  cardboard drum or according to customer specified requirements
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Application: 
 (2R)-2-Deoxy-2-fluoro-2-methyl-D-erythropentonic Acid γ-Lactone 3,5-Dibenzoate is a reactant used in the synthesis of 1'-C-cyano-2'-fluoro-2'-C-methyl pyrimidine nucleosides as HCV polymerase inhibitors.intermediates of Sofosbuvir CAS:1190307-88-0.
 

Items of Analysis	Standard of Analysis		Test Results
Appearance	White to off-white solid or light brown solid		Off-white solid
Identification (IR)	IR spectrum match with reference standard		Conforms
Identification (HPLC)	The retention time of the main peak consistent with the reference		Conforms
Purity (HPLC, %area)	≥98		99.0
Assay (HPLC, %w/w)	97.5～102.0		98.6
Impurity (HPLC, %area)	2-α Chlorinated impurity and 2-β Chlorinated impurity	≤0.70	0.32
	2-α Hydroxyl impurity and 2-β Hydroxyl impurity	≤0.20	Not detected
	Other single impurities	≤0.30	RRT=0.64   0.22
		Report other impurities with RRT which assay is more than 0.05	RRT=1.14   0.23
	Total impurity	≤2.0	0.78
L-Enantiomer (HPLC, %area)	≤0.15		Not detected
Water (K.F., %w/w)	≤0.10		0.04
Loss on drying  (105℃,1h,%w/w)	≤0.50		0.01
Specific rotation	+130°～+140°		+135°
Residue on Ignition (%w/w)	≤0.50		0.03
Conclusion	Conforms to Factory Standard

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